Publications
Single-molecule characterization and super-resolution imaging of alzheimer's disease-relevant tau aggregates in human samples
2024 | Angewandte Chemie | Böken D, Cox D, Burke M, Lam JYL, Katsinelos T, Danial JS, Fertan E, McEwan WA, Rowe JB, Klenerman D.
Single-molecule observations of human small heat shock proteins in complex with aggregation-prone client proteins
2024 | BioRxiv | Rice L, Marzano N, Cox D, van Oijen A, Ecroyd H
Replicative aging impedes stress-induced assembly of a key human protein disaggregase
2023 | BioRxiv | Mathangasinghe Y, Alberts N, Rosado CJ, Cox D, Payne NL, Ormsby AR, Alp KM, Sakson R, Uthishtran S, Ruppert T, Arumugam S, Hatters DM, Kampinga HH, Nillegoda NB
Protein painting reveals pervasive remodeling of conserved proteostasis machinery in response to pharmacological stimuli
2022 | NPJ Systems Biology & Applications | Cox D, Ormsby AR, Reid GE, Hatters DM.
Deletion of the plasmodium falciparum exported protein ptp7 leads to maurer's clefts vesiculation, host cell remodeling defects, and loss of surface presentation of emp1
2022 | PLoS Pathogens | Carmo OMS, Shami GJ, Cox D, Liu B, Blanch AJ, Tiash S, Tilley L, Dixon MWA.
Sequence grammar underlying the unfolding and phase separation of globular proteins
2022 | Molecular Cell | Ruff KM, Choi YH, Cox D, Ormsby AR, Myung Y, Ascher DB, Radford SE, Pappu RV, Hatters DM.
A biosensor of protein foldedness identifies increased 'holdase' activity of chaperones in the nucleus following increased cytosolic protein aggregation
2022 | Journal of Biological Chemistry | Raeburn CB, Ormsby AR, Cox D, Gerak CA, Makhoul C, Moily NS, Ebbinghaus S, Dickson A, McColl G, Hatters DM.
A census of hsp70-mediated proteome solubility changes upon recovery from heat stress
2022 | Journal of Proteome Research | Sui X, Cox D, Nie S, Reid GE, Hatters DM.
Pink1 signalling in neurodegenerative disease
2021 | Essays in Biochemistry | Whiten DR, Cox D, Sue CM.
Neurodegenerative disease-associated protein aggregates are poor inducers of the heat shock response in neuronal cells
2020 | Journal of Cell Science | San Gil R, Cox D, McAlary L, Berg T, Walker AK, Yerbury JJ, Ooi L, Ecroyd H.
Nascent mutant huntingtin exon 1 chains do not stall on ribosomes during translation but aggregates do recruit machinery involved in ribosome quality control and rna
2020 | PLoS One | Ormsby AR, Cox D, Daly J, Priest D, Hinde E, Hatters DM.
N- and c-terminal regions of αb-crystallin and hsp27 mediate inhibition of amyloid nucleation, fibril binding, and fibril disaggregation
2020 | Journal of Biological Chemistry | Selig EE, Zlatic CO, Cox D, Mok YF, Gooley PR, Ecroyd H, Griffin MDW.
Arginine in c9orf72 dipolypeptides mediates promiscuous proteome binding and multiple modes of toxicity
2020 | Molecular & Cellular Proteomics | Radwan M, Ang CS, Ormsby AR, Cox D, Daly JC, Reid GE, Hatters DM.
Widespread remodeling of proteome solubility in response to different protein homeostasis stresses
2020 | PNAS | Sui X, Pires DEV, Ormsby AR, Cox D, Nie S, Vecchi G, Vendruscolo M, Ascher DB, Reid GE, Hatters DM.
Protein aggregation in cell biology: an aggregomics perspective of health and disease
2020 | Seminars in Cell & Developmental Biology | Cox D, Raeburn C, Sui X, Hatters DM.
Single-molecule characterization of the interactions between extracellular chaperones and toxic α-synuclein oligomers
2018 | Cell Reports | Whiten DR, Cox D, Horrocks MH, Taylor CG, De S, Flagmeier P, Tosatto L, Kumita JR, Ecroyd H, Dobson CM, Klenerman D, Wilson MR.
The small heat shock protein hsp27 binds α-synuclein fibrils, preventing elongation and cytotoxicity
2018 | Journal of Biological Chemistry | Cox D, Whiten DR, Brown JWP, Horrocks MH, San Gil R, Dobson CM, Klenerman D, van Oijen AM, Ecroyd H.
A biosensor-based framework to measure latent proteostasis capacity
2018 | Nature Communications | Wood RJ, Ormsby AR, Radwan M, Cox D, Sharma A, Vöpel T, Ebbinghaus S, Oliveberg M, Reid GE, Dickson A, Hatters DM.
The small heat shock proteins αb-crystallin (hspb5) and hsp27 (hspb1) inhibit the intracellular aggregation of α-synuclein
2017 | Cell Stress Chaperones | Cox D, Ecroyd H.
Small heat-shock proteins prevent α-synuclein aggregation via transient interactions and their efficacy is affected by the rate of aggregation
2016 | Journal of Biological Chemistry | Cox D, Selig E, Griffin MD, Carver JA, Ecroyd H.
The structured core domain of αb-crystallin can prevent amyloid fibrillation and associated toxicity
2014 | PNAS | Hochberg GK, Ecroyd H, Liu C, Cox D, Cascio D, Sawaya MR, Collier MP, Stroud J, Carver JA, Baldwin AJ, Robinson CV, Eisenberg DS, Benesch JL, Laganowsky A.
Preventing α-synuclein aggregation: the role of the small heat-shock molecular chaperone proteins
2014 | Biochimica et Biophysica Acta | Cox D, Carver JA, Ecroyd H.